Genistein is soluble in chloroform:methanol(1:1[v:v],10 mg/ml),yielding a clear, faint to light yellow solution. Stock solutions of genistein in DMSO(up to a concentration of 100 mM) have been prepared.Genistein is practically insoluble in cold water;slightly soluble in hot water, hot ethanol, and hot methanol and soluble in hot 80% ethanol, hot 80% methanol,hot acetone, and pyridine.