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It is a semiconductor refrigeration equipment with AIoT functions and the first AIoT smart networked refrigeration box in the world. It is light and compact, featuring low-power power supply, 12V high-efficiency refrigeration, intelligent temperature control, AI digital display, and over-temperature alarm. It can be powered by household electricity, vehicle power, power banks, and other sources. The IoT version has the unique advantages of AIoT networked boxes, such as WeChat mini-program connection, box opening monitoring, medication registration, and medication reminder. The temperature in the space is adjusted and controlled through the AIoT temperature monitoring system to meet the refrigeration requirements of biological refrigerants.