Cream contains fucoidan of seaweed extract with excellent anti-bacterial, anti-inflammatory and soothing effect, glycosaminoglycans of sea squirts bark extract with excellent cell regeneration, wrinkle diminishing, collagen generation and moisturizing effect, and other beneficial natural extracts like sophora extract, grapefruit extract, eucalyptus extract, clove flower extract, etc. to relieve and improve atopic skin inflammation, prevent skin dehydration, prolong efficacy, and enhance skin moisturization.