COVID-19 Diagnosis and Treatment Plan (Trial Version 7)
IgM/IgG antibody test is included in the diagnostic criteria!
On March 3, 2020, the National Health Commission of the People's Republic of China issued
"COVID-19 Diagnosis and Treatment Plan (Trial Version 7)n and interpreted it. The latest diagnostic
Criteria are:
Explain the "clustered disease cases" in epidemiology; that is, "2 or more cases of fever and/or respiratory symptoms in a small area such as family; office, school class, etc. within 2 weeks."
The "decreased lymphocyte count" in clinical manifestations is replaced with "normal or decreased lymphocyte count."
On the basis of nucleic acid test and sequencing, "serological test" is newly added for disease case determination, that is, wSARS-CoV-2 specific IgM antibodies and IgG antibodies are positive" or"SARS-CoV-2 specific IgG antibodies are changed from negative to positive, or increased by 4 times or higher in recovery phase compared with acute phase" is applicable to disease determination.
In addition, serological test has been added to clinical manifestations: SARS-CoV-2 specific IgM antibodies are mostly positive after 3~5 days of onset; IgG antibody titer is increased by 4 times or higher during recovery phase compared with acute phase.
Source: Central People's Government of the People's Republic of China
http://www.gov.cn
IgM and IgG are the first antibodies appearing in the human immune system during infection. When detecting acute SARS-CoV-2 infection, IgM and IgG antibodies have the advantages of high sensitivity, early diagnosis, and the ability to judge whether a suspect is infected.
IgM and IgG antibodies can only be produced after several days of viral infection, and the specific time may vary between individuals.